Premier Sponsor
Halo Labs
ANALYTICAL TESTING
Halo Labs develops innovative instrumentation to count and characterize subvisible and visible particles. A plate-based approach enables low-volume, high-throughput, fully automated particle imaging, and analysis.
Go to our website: www.halolabs.com/
Latest Protocols and Applications
Protocol
Is Your AAV Payload Impacting Stability? Find out with Aura GT
Adeno-associated viruses (AAVs) have transformed gene therapies by enabling the targeted delivery of therapeutic genetic payloads. However, the amount of AAV material available is consistently in short supply due to its inherently expensive, time-consuming, and laborious production process. This ham... More
Protocol
USP Compendial Particle Measurements with the Aura System
The Aura platform provides a rapid and robust USP 788 compendial method for subvisible particle analysis, a critical quality attribute. It can handle a wide range of sample types and can analyze anywhere from 5 µL to 10 mL of sample, enabling continuity of method from developability assessment to lo... More
Protocol
USP Particle Count Standards with Aura and Particle Vue 3.1
All membrane microscopy methods must generate accurate and reproducible counts for bead counting standards. We present a validated methodology for accurately counting United States Pharmacopeia (USP) microsphere count standards on Aura systems by seamlessly calculating the cumulative area of all the... More
Protocol
Evaluate Cell Therapy Product Purity with Aura CL
The CAR-T development workflow is a multi-step process that includes transfection of T cells with a viral vector to express a chimeric antigen and activation/expansion of the CAR-T using a molecule like a Dynabead conjugated to CD3/CD28. Each of these steps is a potential source of contamination tha... More
Protocol
Detect Specific Protein Aggregates in Biologic Formulations with the Aura Immunoassay
Biologic co-formulations target multiple pharmacologically active sites to increase therapy efficacy. However, either biologic can be a source of protein aggregation that can negatively influence the product’s safety, efficacy, and therapy. Aura systems are the only particle analyzer that can pinpoi... More