Protocol Primers
Technical briefs on current and emerging biotech protocols.
Primer
Planning Your Next Chemogenetic Experiment
Mar 7, 2022
Chemogenetic experiments have been used to study a wide variety of behaviors, such as triggers for substance abuse,eating disorders, obesity, obesity-associated metabolic abnormalities, long term memory, hypertension, locomotor ability, as well as pain, startle, and fear responses. For instance,Hori... More
Primer
Immunodiagnostics in the Post-Covid Era
Feb 22, 2022
The benefits of globalization have ushered in the reality of fast-spreading infectious diseases. This has made the quick development of preventive vaccines and immune therapies imperative. Spread of pathogens through rapid and constant travel is compounded by the multipronged challenges ranging from... More
Primer
Dried Blood Spot Testing: Advantages and Disadvantages
Feb 7, 2022
In vitro diagnostics, marketed directly to consumers without the involvement of a health care provider are called direct-to-consumer tests, or DTC, which are facilitated through easy-to-collect sample matrices such as dried blood spots (DBS), saliva, or swabs that allow the safe and stable transport... More
Primer
Ensuring Immunodiagnostic Efficacy with Pathogen Evolution
Jan 18, 2022
Viruses mutate frequently evolving into new variants and strains over time. Antigenic drift is the process of random genetic mutations of an infectious agent resulting in minor changes in proteins called antigens. These copying errors occur when the virus replicates. Over time, these mutations can r... More
Primer
Testing Host Immune Responses and Transmissibility
Jan 3, 2022
Nonspecific, innate immune response is the first line of defense against invading pathogens. Cells of the innate immune system such as macrophages, natural killer cells, and dendritic cells prevent the spread of foreign pathogens throughout the body.An innate immune response also triggers specific a... More
The Latest
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Zebrafish Tumor Graft Transplantation to Grow Tumors In Vivo That Engraft Poorly as Single Cell Suspensions -
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An Automated Low-Cost Swim Tunnel for Measuring Swimming Performance in Fish -
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A Rabbit Femoral Condyle Defect Model for Assessment of Osteochondral Tissue Regeneration -
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Cartilage Assessment Requires a Surface Characterization Protocol: Roughness, Friction, and Function -
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Optimized Protocol for Accurate Titration of Adeno-Associated Virus Vectors -
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Single-Use Capture Purification of Adeno-Associated Viral Gene Transfer Vectors by Membrane-Based Steric Exclusion Chromatography - More