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GEN Protocols


Spatial Biology Tools and Techniques

Date: August 15, 2022, 11:00 am - 12:00 pm ET

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Single-cell spatial phenotyping is transforming biomedical research in fields ranging from oncology to neuroscience.  This GEN Protocols Mixer focuses on technological developments and protocols that have enabled spatial approaches in biology. We will explore novel applications of the technology in different fields including renal disease and obesity, and discuss how you can design a study using spatial biology techniques while ensuring data integrity and reproducibility. We’ll talk about ways to approach a testable hypothesis using spatial tools and techniques and analytical methods that can help you translate your data into meaningful biologically-relevant findings. 

Spatial biology combines individual single-cell molecular data and places it in the context of the cellular landscape and tissue microenvironment. This context is conventionally lost when tissue samples are lysed to detect biomolecules in RNA sequencing, next-generation sequencing, or mass spectrometry-based approaches alone. Spatial approaches therefore result in more meaningful biological insights across multiple dimensions since scientists can now query not only changes in the expression levels of different biomolecules, but also the specific in vivo locations of these changes. 

A live Q&A will follow the discussion, offering a chance to pose questions to our expert panelists.

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Julia Kennedy-Darling, PhD, is the Senior Director of Research and Development at Akoya Biosciences.   


Elizabeth Neumann, PhD, is an assistant professor in the chemistry department at the University of California at Davis.