Genome Editing
Application
Knock-out cell lines and their use in signaling pathways
Knock-out (KO) cell lines are powerful tools to study disease mechanisms, such as the effect of gene disruption on downstream pathways. In this application note, we highlight the effectiveness of Abcam KO cell lines that can be used to investigate signaling pathways, in this case, the TRAIL pathway.... More
Application
Benchling for Industrial Biotech R&D
Industrial biotechnology is transforming traditional manufacturing technologies by providing more eco-friendly approaches like bioprocessing and biomanufacturing. However, there are several hurdles for industrial biotech companies seeking to develop next-gen strains, novel processes, and new applica... More
Application
Benchling & Beam Therapeutics: A Two-Pronged Approach to Automation for Gene Therapy Research
Beam Therapeutics is developing a new class of genetic medicines using novel base editing technology that enables them to edit precise sets of base pairs without introducing a double-stranded break in the DNA. Beam needs to evaluate thousands of biological samples each week, but their digital infras... More
Application
Benchling & uniQure: Bringing a gene therapy pioneer from paper to the cloud
uniQure is rapidly advancing a pipeline of AAV-based gene therapies to treat patients with hemophilia, Huntington’s disease, and other severe genetic diseases, but they needed a digital solution that could track their gene therapy workflows end-to-end and enable international collaboration. Learn ho... More
Application
Benchling for Gene Therapy & Gene Editing R&D
Modern gene therapy requires investigation of a wide variety of genes of interest, engineering of delivery vectors, and optimization of vector production processes. This necessitates a strong digital foundation to comprehensively characterize gene therapy candidates to bring the best products into t... More
The Latest
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Protocol
Zebrafish Tumor Graft Transplantation to Grow Tumors In Vivo That Engraft Poorly as Single Cell Suspensions -
Protocol
An Automated Low-Cost Swim Tunnel for Measuring Swimming Performance in Fish -
Protocol
A Rabbit Femoral Condyle Defect Model for Assessment of Osteochondral Tissue Regeneration -
Protocol
Cartilage Assessment Requires a Surface Characterization Protocol: Roughness, Friction, and Function -
Protocol
Optimized Protocol for Accurate Titration of Adeno-Associated Virus Vectors -
Protocol
Single-Use Capture Purification of Adeno-Associated Viral Gene Transfer Vectors by Membrane-Based Steric Exclusion Chromatography - More