Computational Biosciences
Computational Biosciences
Application
Benchling for Industrial Biotech R&D
Industrial biotechnology is transforming traditional manufacturing technologies by providing more eco-friendly approaches like bioprocessing and biomanufacturing. However, there are several hurdles for industrial biotech companies seeking to develop next-gen strains, novel processes, and new applica... More
Application
Benchling & Beam Therapeutics: A Two-Pronged Approach to Automation for Gene Therapy Research
Beam Therapeutics is developing a new class of genetic medicines using novel base editing technology that enables them to edit precise sets of base pairs without introducing a double-stranded break in the DNA. Beam needs to evaluate thousands of biological samples each week, but their digital infras... More
Application
Benchling & Jounce Therapeutics: Migrating to an All-in-One Cloud Solution Saves Time on Data Management
Jounce Therapeutics uses a number of different analytical techniques to identify biomarkers in the tumor microenvironment (TME) that can help them match their drug candidates with the right patients. But they needed a way to manage all their assay and antibody data from concept to IND across differe... More
Application
Benchling & uniQure: Bringing a gene therapy pioneer from paper to the cloud
uniQure is rapidly advancing a pipeline of AAV-based gene therapies to treat patients with hemophilia, Huntington’s disease, and other severe genetic diseases, but they needed a digital solution that could track their gene therapy workflows end-to-end and enable international collaboration. Learn ho... More
Application
Benchling for Antibody R&D
Innovations in monoclonal antibody technology, bispecifics, and antibody-drug conjugates continue to push the envelope of antibody efficacy and safety. But the industry requires a new kind of digital solution that can offer a holistic view of antibody research and development, integrating large and ... More
Application
Benchling for Gene Therapy & Gene Editing R&D
Modern gene therapy requires investigation of a wide variety of genes of interest, engineering of delivery vectors, and optimization of vector production processes. This necessitates a strong digital foundation to comprehensively characterize gene therapy candidates to bring the best products into t... More
Application
The Benchling Life Sciences R&D Cloud
Life science R&D is becoming more complex. Companies need software built for the new way of doing science, or they risk falling behind the next generation of therapeutic development. Enter Benchling. Benchling connects the entire R&D lifecycle — from project documentation and data acquisition to seq... More
Protocol
Detergent-Free Nuclei Isolation
- OMICS
- Drug Discovery
- Translational Medicine
- Computational Biosciences
- Cancer Research
- Genome Editing
A novel spin column-based approach to isolate intact single nuclei from tissues (fresh or frozen) and cells without using a detergent. The protocol is fast, easy, and reliable, producing high-quality single nuclei with minimized clumping and possible leakage of the nuclear envelope. The protocol is ... More
Application
Benchling for RNA Therapeutics R&D
Because RNA therapeutics can target conditions that small molecules and proteins cannot address, researchers are now on the verge of treating previously “undruggable” diseases. From the approval of the first antisense oligonucleotide, aptamer, and siRNA, to the now famous launch of mRNA-based COVID-... More
Application
Benchling for Cell Therapy R&D
Cell therapies such as stem cells, CAR T cells, and TCR have been of significant interest in research over the past few decades. The FDA approval of CAR T therapies has led to renewed interest in the field. As companies rush to bring more novel cell therapies to the market, they face several R&D com... More
The Latest
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Application
A Fast and High Precision Influenza Vaccine Potency Assay -
Application
Strategies for the Development of a High Throughput Octet® Bio-Layer Interferometry Method to Measure Pharmacokinetics of Monoclonal Antibodies in Preclinical Animal Models -
Application
Effective Dead Cell Depletion using Microbubbles Delivers High Yield -
Protocol
Preclinical Optimization and Safety Studies of a New Lentiviral Gene Therapy for p47phox-Deficient Chronic Granulomatous Disease -
Protocol
High-Throughput In Vitro, Ex Vivo, and In Vivo Screen of Adeno-Associated Virus Vectors Based on Physical and Functional Transduction -
Protocol
Effective Targeting of Multiple B-Cell Maturation Antigen–Expressing Hematological Malignances by Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor T Cells - More