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GEN Protocols

Computational Biosciences

Computational Biosciences

Application

Benchling for Industrial Biotech R&D

Industrial biotechnology is transforming traditional manufacturing technologies by providing more eco-friendly approaches like bioprocessing and biomanufacturing. However, there are several hurdles for industrial biotech companies seeking to develop next-gen strains, novel processes, and new applica... More


Application

Benchling & Beam Therapeutics: A Two-Pronged Approach to Automation for Gene Therapy Research

Beam Therapeutics is developing a new class of genetic medicines using novel base editing technology that enables them to edit precise sets of base pairs without introducing a double-stranded break in the DNA. Beam needs to evaluate thousands of biological samples each week, but their digital infras... More


Application

Benchling & Jounce Therapeutics: Migrating to an All-in-One Cloud Solution Saves Time on Data Management

Jounce Therapeutics uses a number of different analytical techniques to identify biomarkers in the tumor microenvironment (TME) that can help them match their drug candidates with the right patients. But they needed a way to manage all their assay and antibody data from concept to IND across differe... More


Application

Benchling & uniQure: Bringing a gene therapy pioneer from paper to the cloud

uniQure is rapidly advancing a pipeline of AAV-based gene therapies to treat patients with hemophilia, Huntington’s disease, and other severe genetic diseases, but they needed a digital solution that could track their gene therapy workflows end-to-end and enable international collaboration. Learn ho... More


Application

Benchling for Antibody R&D

Innovations in monoclonal antibody technology, bispecifics, and antibody-drug conjugates continue to push the envelope of antibody efficacy and safety. But the industry requires a new kind of digital solution that can offer a holistic view of antibody research and development, integrating large and ... More


Application

Benchling for Gene Therapy & Gene Editing R&D

Modern gene therapy requires investigation of a wide variety of genes of interest, engineering of delivery vectors, and optimization of vector production processes. This necessitates a strong digital foundation to comprehensively characterize gene therapy candidates to bring the best products into t... More


Application

The Benchling Life Sciences R&D Cloud

Life science R&D is becoming more complex. Companies need software built for the new way of doing science, or they risk falling behind the next generation of therapeutic development. Enter Benchling. Benchling connects the entire R&D lifecycle — from project documentation and data acquisition to seq... More


Protocol

Detergent-Free Nuclei Isolation

A novel spin column-based approach to isolate intact single nuclei from tissues (fresh or frozen) and cells without using a detergent. The protocol is fast, easy, and reliable, producing high-quality single nuclei with minimized clumping and possible leakage of the nuclear envelope. The protocol is ... More


Application

Benchling for RNA Therapeutics R&D

Because RNA therapeutics can target conditions that small molecules and proteins cannot address, researchers are now on the verge of treating previously “undruggable” diseases. From the approval of the first antisense oligonucleotide, aptamer, and siRNA, to the now famous launch of mRNA-based COVID-... More


Application

Benchling for Cell Therapy R&D

Cell therapies such as stem cells, CAR T cells, and TCR have been of significant interest in research over the past few decades. The FDA approval of CAR T therapies has led to renewed interest in the field. As companies rush to bring more novel cell therapies to the market, they face several R&D com... More